CANCER CARE AT THE LONDON CLINIC

ABOUT THE LONDON CLINIC

Established in 1932 and situated in the heart of London’s medical community, The London Clinic is one of the UK’s largest private hospitals, dedicated to providing the best, personalised healthcare with a breadth of surgical and medical expertise.

The London Clinic has a number of premises across Harley Street and Devonshire Place, including:

- Our main hospital building spans Harley Street and Devonshire Place, looking out onto Marylebone Road. It has eight floors, each with dedicated nursing teams covering specialty areas of medicine and surgery. The hospital comprises of 234 beds, 10 theatres (including a Hybrid threatre and two minimally invasive and day surgery theatres), an endoscopy unit, a radiology unit, dialysis and a 13-bed Intensive Care Unit.

- The Duchess of Devonshire Wing, which was completed and opened in 2010 is located at 22 Devonshire Place. The facility, which is built on eight floors, includes state-of-the-art radiotherapy, chemotherapy suites and 47 dedicated patient bedrooms. The Duchess of Devonshire Wing is also home to the café, on the ground floor, which is open to patients and visitors.

- The London Clinic Eye Centre at 119 Harley Street is a dedicated building which provides consulting, tests and treatments for a range of eye conditions.

- Consulting rooms and diagnostic services at 5 Devonshire Place are provided from this modern, 6 storey building. Services include blood tests, health assessments and diagnostic imaging.

- Consulting room suites are also located at 145 Harley Street, 120 Harley Street and 116 Harley Street.

- Our administration building is located at 1 Park Square West.

The London Clinic is a charity which is governed by the Chairman and Board of Trustees. They, in turn, delegate the day to day management of the Clinic to the Executive Board of Directors.

Over 1,000 staff work in specialist teams at The London Clinic across all clinical and non-clinical areas, combined with over 300 consultant surgeons and physicians.

XPERT CARE AND DEDICATED SUPPORT
The haematology consultants at The London Clinic treat a wide range of blood disorder conditions and are leaders in their areas of expertise.

Our specialist nursing and support teams work closely with these world-leading consultants, supported by some of the most modern treatment technology available.

CONDITIONS TREATED INCLUDE:
Anaemia

Blood coagulation

Hodgkin’s disease

Leukaemia

Lymphoma

Myeloma

CAR-T IMMUNOTHERAPY FOR B-CELL LYMPHOMA
The London Clinic offers this transformative cell therapy to cancer patients. CAR-T cell therapy is a cutting-edge treatment for adults with diffuse large B-cell lymphoma.

Immune cells are collected from patients and genetically modified to destroy cancer cells. This revolutionary therapy can offer hope for people who have no other treatment options.

The London Clinic is one of the few hospitals offering this revolutionary treatment.

LONDON HAEMATOLOGY
The consultants who make up London Haematology have special interests in all aspects of haematology, including:
Leukaemias
Myeloma
Anaemia
Coagulation
thrombotic disorders

The work is done at our specialist centre for adult bone marrow transplantation and stem cell harvesting.

WE PROVIDE THE BEST CANCER CARE FROM DIAGNOSIS AND TREATMENT, TO SUPPORT AND BEYOND
The Duchess of Devonshire Wing is our award-winning cancer centre specially designed for patients receiving cancer treatment. The facility encompasses all cancer treatment modalities under one roof, bringing experts from a range of specialisms to work together as a multidisciplinary team (MDT) around your treatment needs.

From the moment you arrive at our cancer centre, we’re by your side. Our teams support you throughout your care, including diagnosis, treatment, supportive services and palliative care.

Immune cells are collected from patients and genetically modified to destroy cancer cells. This revolutionary therapy can offer hope for people who have no other treatment options.

The London Clinic is one of the few hospitals offering this revolutionary treatment.

INTRA-OPERATIVE RADIOTHERAPY (IORT) TREATMENTS FOR CANCER
Intra-operative radiotherapy is when a very localised, high dose of radiation is given at the same time as the surgical treatment. The London Clinic is one of the few sites in the UK to offer treatment with the Carl Zeiss Intrabeam® system - a miniaturised X-ray device which is located within our on-site theatres.

The London Clinic works with leading surgeons and oncologists in the field to offer IORT for these indications:

OUR OTHER INNOVATIONS
We are a pioneering cancer treatment centre, and have been driving forward advancements in care since the original hospital opened in 1932.

We were the first private hospital in the UK to offer cancer patients advanced diagnostic scanning with the new, state-of-the-art Siemens MAGNETOM Vida 3T MRI scanner

We were the first private hospital in the world to pilot Proximie augmented reality technology, during a robotic prostate cancer operation.

We are also:

The only private hospital in London offering adaptive radiotherapy for bladder cancer cases

The use of CyberKnife, the only robotic radiosurgery system in the world that can treat tumours throughout the body

The first hospital in the UK to offer our prostate cancer patients a new treatment called SpaceOAR®

HEART AND CHEST SERVICES

The London Clinic provides a number of procedures to assess the health of your heart. Our diagnostic services facility at 5 Devonshire Place offers a range of heart investigations, helping your cardiologist to develop a treatment programme tailored to your needs.

The following cardiac investigations are available at the London Clinic:

Electrocardiogram (ECG) and ECG monitoring, including ambulatory 24-hour or 7-day continuous ECG monitoring and event monitoring
Echocardiogram, including contrast echocardiography and transoesophageal echocardiography
Blood pressure monitoring, 24-hour blood pressure monitoring
Exercise stress testing

All of these tests can establish the health of the heart and can detect potential problems.

SPECIALIST HEART SERVICES

CARDIAC IMAGING AT THE LONDON CLINIC
The London Clinic is one of the few private hospitals in central London to offer a comprehensive, multi-modality cardiac imaging service. Our purpose-built stress echocardiography laboratory permits a daily, consultant-led service.

As opposed to invasive techniques, which require catheters to be inserted into the heart, non-invasive tests are safer, easier to perform, and can be used to detect various heart conditions.

These range from reduced blood flow that supplies the heart muscle (known as coronary artery disease) to abnormalities that weaken the capacity of the heart to pump blood.

THE CARDIO-ONCOLOGY SERVICE AT THE LONDON CLINIC
WHAT IS CARDIO-ONCOLOGY?
Cardio-Oncology is the management of cardiovascular complications for cancer patients. Cancer treatment (both chemotherapy and radiotherapy) can potentially cause a variety of heart problems.

CARDIAC COMPLICATIONS OF CANCER THERAPY
Common chemotherapies (e.g. Herceptin, anthracyclines/doxorubicin/daunorubicin, R-CHOP, R-ESHAP, Velcade, Avastin, ABVD, FOLFOX, FOLFORI) can damage the heart muscle, coronary arteries and cause irregular heartbeat.

Potential cardiac problems of therapies include heart failure, myocarditis (heart muscle inflammation), arrhythmias (e.g. AF or atrial fibrillation) coronary spasm and heart attacks.

Radiotherapy can also lead to cardiac complications in some patients, with the most common early problem being an inflammation of the heart muscle and lining (myopericarditis).

Both chemotherapy and radiotherapy can cause cardiac complications months to many years down the line. These include the development of heart failure, heart valve disease and early coronary artery disease (increasing the risk of heart attacks at a younger age).

ROLE OF THE CARDIO-ONCOLOGY SERVICE
The Cardio-Oncology service at The London Clinic plays a key role in preventing the development of complications and manging them if they occur.

Dr Arjun Ghosh is the first Consultant Cardiologist in the UK to be appointed with the specific remit of managing cancer patients with heart problems. He has now brought this expertise to the London Clinic to enable patients to receive world-class Cardio-Oncology care.

PRE-TREATMENT CARDIAC RISK ASSESSMENT
The Cardio-Oncology service can assess the cardiac risk of a patient before the initiation of cancer treatment. The assessment includes a clinical examination followed by specialised cardiac tests e.g. echocardiography (ultrasound scanning of the heart looking at the heart muscle and valves).

Home 24 hour monitoring of the blood pressure and heart rate may be required to further quality cardiac risk. Cardiovascular risk profile blood tests (blood sugar, cholesterol, kidney and liver function) complete the comprehensive assessment.

MONITORING DURING CARDIAC TREATMENT
Cancer patients receiving potentially cardiotoxic therapy need to be monitored during the course of their treatment. Monitoring will detect cardiac abnormalities at an early stage to allow the prompt use of cardiac therapy. This may take the form of periodic echocardiography and blood tests.

POST-TREATMENT CARDIAC LATE-EFFECTS
Patients in the Late Effects setting are followed up to detect cardiac complications months to years after the completion of cancer treatment. These reviews include a clinical examination and history, undertaking appropriate ancillary investigations (e.g. ECG and echocardiography) as required.

RESEARCH IN CARDIO-ONCOLOGY
Dr Ghosh is heavily involved in Cardio-Oncology education and research, having published a number of papers in the field and is regularly invited to speak, nationally and internationally on the topic.

DIABETES AND ENDOCRINOLOGY AT THE LONDON CLINIC
The London Clinic Centre for Diabetes and Endocrinology is staffed by internationally-renowned physicians and dedicated specialist nurses.

HOLISTIC APPROACH TO ENDOCRINE AND DIABETES CONDITIONS
Our consultants and specialist nurses work together to support our patients with up-to-date clinical care, emotional support, on-going education and to provide a personalised, bespoke service.

Managing endocrine and diabetes requires a multi-faceted approach.

We work as a team to help patients understand their conditions, empowering and encouraging them to make their own lifestyle choices, be that mountaineering or simply maintaining a good healthy lifestyle.

People find our service particularly helpful if they:

Have been recently diagnosed
Want to understand the impact of a long term condition on their quality of life
Need advice if they are planning a baby or require intensive monitoring during pregnancy
Are interested in getting information on new treatments
Need extra support and advice before, during or after surgery.

DIAGNOSTIC TESTS AND SCANS AT THE LONDON CLINIC

The imaging department at The London Clinic has over 60 full-time staff who provide a full diagnostic imaging service.

We provide a comprehensive range of both inpatient and outpatient investigative procedures in an efficient, comfortable and stress-free environment.

Equipment is continually updated and the technology is in place to offer the latest diagnostic imaging techniques as well as a full nuclear medicine service.

Nuclear medicine is widely used in oncology and also makes it possible for gastroenterologists to assess gut transit, orthopaedic surgeons to investigate joint infections and for endocrinology specialists to investigate endocrine function.

We combine the most advanced technology and facilities with leading radiology expertise to provide a first-class patient experience and world-class reporting.

We are committed to continual upgrading of our software and systems to make sure that our equipment is always at the leading edge of clinical practice.

Our specialist Interventional Radiologists also offer therapeutic procedures that are guided by imaging technology.

INTRA-OPERATIVE RADIOTHERAPY (IORT) TREATMENTS FOR CANCER
Intra-operative radiotherapy is when a very localised, high dose of radiation is given at the same time as the surgical treatment.

The London Clinic is one of the few sites in the UK to offer treatment with the Carl Zeiss Intrabeam® system - a miniaturised X-ray device which is located within our on-site theatres.

The London Clinic works with leading surgeons and oncologists in the field to offer IORT for these indications:

INTERNATIONAL CLINICAL TRIAL FOR BRAIN CANCER
Intra-operative radiotherapy (IORT) is a pioneering radiotherapy technique for patients with GBM (Glioblastoma Multiforme), a brain cancer with a high mortality rate.

The London Clinic is the first and currently only site in the UK to offer IORT for GBM, as part of the INTRAGO II phase 3 clinical trial, and one of 12 international hospitals taking part.

The INTRAGO II trial aims to bridge the inevitable gap between surgery and post-operative radiotherapy, and investigate the benefit of the treatment for glioblastoma, to help patients now and in the future.

For further information on the trial, or patient suitability please contact:

Tel +44 (0)203 219 3315

NEURO INTRA-OPERATIVE RADIOTHERAPY (IORT)
IORT is delivered with the Carl Zeiss Intrabeam® system - a miniaturised X-ray device which is located within our on-site theatres. During surgery and after the tumour is removed, a high dose of radiotherapy is administered directly to the tumour cavity, aimed at clearing any microscopic disease which may have been left behind. Currently, IORT is only offered as part of a clinical, randomised phase 3 trial.

IORT removes the unnecessary delay in administering radiotherapy treatment to the patient. Radiotherapy is applied following surgery with patient under anaesthetic prior to closure. This technique is safe and allows local dose intensification.

WHAT IS GLIOBLASTOMA MULTIFORME (GBM)?
GBM is the most common malignant brain cancer, affecting roughly 2,000 adults every year in the UK, with figures predicted to rise over the years to come.

GBM is primarily treated with a combination of surgery, chemotherapy and external beam radiotherapy. Despite this, due to the high growth rate of cells there is a high chance the tumour can reoccur.

IORT shows great promise in the treatment of glioblastoma. At The London Clinic, a boost dose of up to 30Gy may be delivered, in addition to standard post operative radiotherapy, to better control the cancer cells left behind in the tumour bed, before any cells start to regrow.

INTRAGO II, PHASE 3 CLINICAL TRIAL
INTRAGO II is an international, multi-centre phase 3, randomised trial. Patients are randomly allocated between two different trial groups. In one group, the patient will receive the standard care of treatment including radiotherapy and chemotherapy. In the other, the patient will receive the standard care with an additional boost of intra-operative radiotherapy (IORT) delivered during surgery. All patients are carefully followed-up to monitor their condition.

WHO CAN APPLY FOR THE CLINICAL TRIAL?
Patients who have a suspected GBM without any previous radiotherapy or chemotherapy, can be considered for the trial. Your doctor will advise you if you are suitable to take part in the INTRAGO II trial. Candidates must be aged 18 or older and younger than 80, and must not have had previous cranial radiotherapy.

WHY CONSIDER THE IORT INTRAGO II TRIAL
Administered during surgery
Increased local dose
Careful follow up on all patients

THE IORT SERVICE AT THE LONDON CLINIC
The London Clinic supports a comprehensive neurological service, incorporating high-spec linear accelerators for radiotherapy, stereotactic radiotherapy with CyberKnife™, a state-of-the-art intensive care unit (ICU) and a comprehensive rehabilitation and aftercare programme.

Consultant neurosurgeons, Professor Keyoumars Ashkan, Mr Ranj Bhangoo and Consultant Oncologist, Dr Matt Williams, are leading the clinical trial at The London Clinic, and are asking consultant oncologists and neurologists to refer patients for the clinical trial. Participation in this trial reflects our approach to research and innovation, and will provide patients a new treatment option for GBM.

INTRA-OPERATIVE RADIOTHERAPY (IORT) FOR BREAST CANCER

Intra-operative radiotherapy is when a very localised, high dose of radiation is given at the same time as the surgical treatment. The London Clinic is one of the few sites in the UK to offer treatment with the Carl Zeiss Intrabeam® system - a miniaturised X-ray device which is located within our on-site theatres.

The London Clinic works with leading surgeons and oncologists in the field to offer this treatment for Breast, Colorectal and Brain indications.

INTRA-OPERATIVE RADIOTHERAPY FOR BREAST CANCER – TARGIT IORT
Intra-operative radiotherapy (IORT) is an innovative technique in which low-energy X-ray radiation is used to treat suitable patients affected by breast cancer. At the London Clinic, the Carl Zeiss Intrabeam® system is utilised at the time of surgery to precisely deliver the prescribed radiation dose to the site of the cancer. In most cases, this single one-off treatment replaces the traditional external beam radiotherapy technique, normally requiring 3-5 weeks of therapy over 15-25 separate visits to the hospital.

The Intrabeam® system has been subject to extensive research in order to compare IORT in relation to conventional whole-breast external beam radiotherapy. Between 2000-2012, the TARGIT-A randomised trial recruited over 3000 patients across Europe. Results published indicate that when IORT is given at the time of the surgery the success rate is similar to conventional treatment and notably IORT patients exhibited fewer associated side-effects.

The London Clinic participates in the Targit-R registry which helps ensure that patients are followed-up and safely monitored throughout their treatment and recovery.

THE IORT TEAM AT THE LONDON CLINIC
The London Clinic works with leading specialist surgeons and oncologists, fully trained in up-to-date IORT treatment methods. The London Clinic IORT radiotherapy team consists of physicists and radiographers who provide expertise in the scientific and technical delivery of low energy X-rays.

The team supported delivery of the first privately treated breast IORT patient in the UK, were the first site to utilise specialist “flat applicators” for dose delivery in colorectal applications and supported the UK implementation of the INTRAGO II trial for glioblastoma.

The team have also contributed to research and international conferences in this specialist area.

INTRA-OPERATIVE RADIOTHERAPY (IORT) FOR COLORECTAL CANCER

The London Clinic works with leading surgeons and oncologists in the field to offer this treatment for Breast, Colorectal and Brain indications.

INTRA-OPERATIVE RADIOTHERAPY FOR COLORECTAL CANCER
Colorectal cancer is primarily treated with surgery but in some cases, in order to help reduce the chance of recurrence, intra-operative radiotherapy can be given during the operation. This dose is usually given as a boost in addition to external beam radiotherapy to deliver a safe and optimal dose to help treat the area of disease. The London Clinic works with leading surgeons and oncologists in this field to provide this treatment and were the first in the UK to use the Zeiss Intrabeam system with specifically designed “flat applicators” for colorectal cancer treatments.

The team have also contributed to research and international conferences in this specialist area.

UR NEW 3T MRI SCANNER
The London Clinic is the first private hospital in the UK to offer patients the latest diagnostic imaging with the new Siemens MAGNETOM Vida 3T MRI scanner.

Our radiologists use our innovative 3T MRI scanner to:

Produce ultra sharp imaging
Visualise and monitor changes within the body
Provide greater patient comfort and reduce imaging time
Plan individualised therapy

MAIN NUMBERS

Concierge service: +44 (0) 203 219 3323

International office: +44 (0) 203 219 3266

Invoice and payment enquiries: +44 (0) 207 616 7708

Your call may be recorded for training and monitoring purposes.

MEDICAL SERVICE NUMBERS

Breast services appointments: +44 (0) 207 616 7653

Diagnostics appointments: +44 (0) 207 616 7653

Endoscopy appointments: +44 (0) 207 616 7760

Eye centre appointments: +44 (0) 207 616 7768

Haematology appointments: +44 (0) 207 535 5503

Kidney services appointments: +44 (0) 207 224 5234

Liver services appointments: +44 (0) 207 616 7719

Physiotherapy appointments: +44 (0) 207 616 7651

Radiology appointments: +44 (0) 207 616 7653

THE LONDON CLINIC MAIN HOSPITAL

The London Clinic's main hospital site is where the majority of operations and procedures are performed. The hospital is formed of eight floors and spans Devonshire Place and Harley Street.

The hospital also contains our endoscopy unit, diagnostic imaging services and physiotherapy department, including the hydrotherapy pool.

20 Devonshire Place London

W1G 6BW

+44 (0) 207 935 4444